*************** ANNOUNCEMENT ********************** * University of Utah Mathematical Biology Seminar * *************************************************** Thursday, April 22 at 4 pm in INSCC 110 Speaker: Eirikur Palsson (U of U Math) Title: A three dimensional model of cell movement in multicellular systems. Abstract: We have developed a mathematical model of cell movement in multicellular systems and tissues. This model allows us to simulate and visualize, in three dimensions, individual cell movements in a number of multicellular systems. These include, but are not limited to cell movement during, aggregation and slug stage of Dictyostelium discoideum, embryogenesis, limb formation and wound healing. Here we introduce this model and and show examples of its applications and compare the results with experimental data. Among the simulations we show, is how different cell types can sort out based solely on differences in adhesion. We compare our results to cell sorting experiments done by Steinberg et.al., using values for adhesion within the range of the experimental values, and show that the model reproduces the experiments very well.