How is immune memory regulated? I mathematically model the homeostatic regulation of memory CD8+ T cells via competition for various interleukins (IL-15, IL-2, and IL-7). These cytokines signal survival, proliferation, and apoptosis in CD8+ T cells, and competing effects of these chemicals are likely responsible for the remarkable constancy of the memory CD8+ T cell compartment between infections in adults. A mechanistic mathematical model of memory regulation will be used to analytically explore shifts in the memory T cell repertoire following infection and homeostatic expansion.

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