Dr. Jay Newby

Postdoctoral Fellow

Department of Mathematics

UNC, Chapel Hill

Research

A living cell must function despite ever-present thermal fluctuations that continuously impose random forces into its intricate molecular machinery. Hence, cellular processes are intrinsically stochastic. One example is the kinetic coupling between stochastic molecular motors and microtubules to boost and guide otherwise slow and random diffusive transport of cargo across the cell. Similar kinetic and diffusive processes are at play in extracellular mechanisms, e.g., antibody-based viral immunity. A central theme of my research is understanding how a cell exploits and harnesses intrinsic noise to its advantage.

Selected Publications

JN and Jun Allard. First-passage time to clear the way for receptor-ligand binding in a crowded environment. Phys. Rev. Lett. (in press), 2016.

preprint

JN and M Schwemmer. Effects of moderate noise on a limit cycle oscillator: Counterrotation and bistability. Phys. Rev. Lett., 2014.

preprint journal animation

JN and J Chapman. Metastable behavior in Markov processes with internal states. J. Math. Biol., 2013.

preprint journal

JN, P Bressloff, and J Keener. The role of stochastic potassium channels in spontaneous action potential initiation. Phys. Rev. Lett., 2013.

preprint journal