MATH 6770, Fall 2010
TTh 12:25-1:45am, LCB 222 (LeRoy Cowles Building)
Instructor: |
Peter Kim Office: LCB 313 (LeRoy Cowles Building) Phone: 585-1645 ![(my 3-letter last name)[at symbol]math[dot]utah[dot]edu](../../email_address_scribble.jpg){kind=small}
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Office hours: |
I am available right after lecture, or by appointment via email. |
| Course Info | Recommended Texts | Course Outline |
| Date | Topic | Relevant handouts/papers |
| Tue, Aug 24 (First day of class) | Introduction Cancer stem cells Chronic myelogenous leukemia |
Syllabus.pdf Michor et al. (2005) Dynamics of chronic myeloid leukaemia. Nature |
| Thu, Aug 26 | Chronic myelogenous leukemia Agent-based modeling Age/maturity-structured modeling |
Roeder et al. (2006)
Dynamic modeling of imatinib-treated chronic myeloid
leukemia: functional insights and clinical implications. Nature Medicine
|
| Tue, Aug 31 | Colon cancer Age/maturity-structured modeling |
Johnston et al. (2007)
Mathematical modeling of cell population dynamics in the colonic crypt and in colorectal cancer. PNAS
Johnston et al. (supplementary info) |
| Thu, Sept 2 | Colon cancer |
Komarova et al. (2007) Initiation of Colorectal Cancer: Where do the Two Hits Hit? Cell Cycle Michor et al. (2004) Linear Model of Colon Cancer Initiation. Cell Cycle |
| Tue, Sept 7 | Colon cancer Skin cancer |
van Leeuwen et al. (2009) An integrative computational model for intestinal tissue renewal. Cell Prolif. Eyles et al. (2010)Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J Clin Invest. |
| Thu, Sept 9 | Skin cancer |
Eikenberry et al. (2009) Tumor-Immune Interaction, Surgical Treatment, and Cancer Recurrence in a Mathematical Model of Melanoma. PLoS Comput Biol. |
| Tue, Sept 14 | Hallmarks of cancer HIV, HIV latency |
Hanahan and Weinberg (2000) The Hallmarks of Cancer. Cell Rong and Perelson (2009) Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy. PLoS Comput Biol. |
| Thu, Sept 16 | HIV treatment Memory T cell depletion |
Sedaghat et al. (2008) Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle. PNAS Yates et al. (2007) Understanding the Slow Depletion of Memory CD4+ T Cells in HIV Infection. PLoS Medicine |
| Tue, Sept 21 | Hepatitis C Immune surveillance: NK cells |
Dahari et al. (2007) Triphasic Decline of Hepatitis C Virus RNA During
Antiviral Therapy. Hepatology Merrill (1981) A Model of the Role of Natural Killer Cells in Immune Surveillance - I. J Math Biology |
| Thu, Sept 23 | Immune surveillance: NK cells and T cells |
de Pillis et al. (2005) A Validated Mathematical Model of Cell-Mediated Immune
Response to Tumor Growth. Cancer Research |
| Tue, Sept 28 | Epstein-Barr Virus | yet-to-be-published sources |
| Thu, Sept 30 | Epstein-Barr Virus | yet-to-be-published sources |
| Tue, Oct 5 | Project presentations 1 | |
| Thu, Oct 7 | Project presentations 1 | |
| Oct 12 and 14 | Fall break | |
| Tue, Oct 19 | No class | |
| Thu, Oct 21 | Guest lecture: Cell motility | Mark Zajac |
| Tue, Oct 26 | Regulatory T cells |
Leon et al. (2000) How regulatory CD25(+)CD4(+) T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors J Theor Biol. |
| Thu, Oct 28 | Regulatory T cells and cancer | Leon et al. (2007) How regulatory CD25(+)CD4(+) T cells impinge on tumor immunobiology? On the existence of two alternative dynamical classes of tumors J Theor Biol. |
| Tue, Nov 2 | Adaptive regulatory T cells | Fouchet and Regoes (2008) A Population Dynamics Analysis of the Interaction between Adaptive Regulatory T Cells and Antigen Presenting Cells PLoS ONE |
| Thu, Nov 4 | Cancer therapy |
Kirschner and Panetta (1998) Modeling immunotherapy of the tumor–immune interaction J. Math. Biol. Iliadis and Barbolosi (2000) Optimizing Drug Regimens in Cancer Chemotherapy by an Efficacy–Toxicity Mathematical ModelComputers and Biomedical Research |
| Tue, Nov 9 | Project presentations 2 | |
| Thu, Nov 11 | Project presentations 2 | |
| Tue, Nov 16 |
Tumor invasion & game theory Overview |
Basanta, Hatzikirou, and Deutsch (2008) Studying the emergence of invasiveness in tumours using game
theory Eur. Phys. J. B Bellomo, Li, and Maini (2008) On the foundations of cancer modelling: selected topics, speculations, and perspectives Mathematical Models and Methods in Applied Sciences |
| Thu, Nov 18 | Guest lecture: Risk Assessment for Emerging Infectious Diseases | Damon Toth |
| Tue, Nov 23 | Thanksgiving break | |
| Thu, Nov 25 | Thanksgiving Day | |
| Tue, Nov 30 | No class | |
| Thu, Dec 2 | Guest lecture: Deep brain stimulation and Parkinson's disease | Stephen Odom |
| Tue, Dec 7 | Project presentations 3 | |
| Thu, Dec 9 | Project presentations 3 |