Wednesday November 19, 2003
Yan-Ting Elizabeth Shiu
Department of Bioengineering, University of Utah
Abstract:Vascular endothelial cells line the inner wall of blood vessels and are constantly subjected to shear stress due to blood flow. There is ample evidence that shear stress play a key role in the maintenance of vascular integrity and the guidance of vascular remodeling, as well as the development of vascular diseases. This lecture will address what is currently known regarding the flow-induced mechanotransduction in vascular endothelial cells and the ensuing changes in endothelial cell function. Special emphases will be placed on flow modulation of the migration and intercellular junction of endothelial cells as they pertain to atheroscelerosis development.
For more information contact J. Keener, 1-6089