Hyunjoong "Hune" Kim
Ph.D. Candidate
Department of Mathematics · University of Utah
 
I am a 3rd year graduate student in the Biophysics and Stochastics Research Group at the University of Utah, advised by Professor Paul Bressloff. I am particularly interested in deterministic and stochastic modeling of biological phenomena and related mathematical analysis together with simulations. Currently, I am working on intercellular signaling via direct cell-to-cell contact, which is mediated by actin-based fillaments known as cytonemes, during morphogenesis. Here is my CV.
  [!]   Looking for a postdoctoral position!
  [!]   Summer Research Visit to the NSF-Simons Center for Multiscale Cell Fate Research, UC Irvine (2019).
  [!]   Awarded the Department Summer Research Fellowship (2019).
 
Research
Cytonemed-based morphogenesis
Morphogen protein gradients play an essential role in the spatial regulation of patterning during embryonic development. The most commonly accepted mechanism of protein gradient formation involves the diffusion and degradation of morphogens from a localized source. Recently, there is growing experimental evidence for an alternative mechanism, which is based on cell-to-cell transport via thin actin-rich cellular extensions known as cytonemes. We have developed mathematical models and analyzed both deterministic and stochastic differential equations by cool probability theories together with numerical simulations.
 
  1. H Kim and P C Bressloff. Impulsive signaling model of cytoneme-based morphogen gradient formation Accepted by Physical Biology (2019)
  2. P C Bressloff and H Kim. Search-and-capture model of cytoneme-mediated morphogen gradient formation Physical Review E 99 052401 (2019)
  3. H Kim and P C Bressloff. Direct vs. synaptic coupling in a mathematical model of cytoneme-based morphogen gradient formation SIAM Journal on Applied Mathematics 78 2323-2347 (2018)
  4. P C Bressloff and H Kim. Bidirectional transport model of morphogen gradient formation via cytonemes Physical Biology 15 026010 (2018)
Intrinsic noise in active transport model of cell length control
A fundamental issue in cell biology is how cells regulate their size. There has been a lot of modeling studies on cell length control with the active transport mechanism. One primary assumption of most previous studies is that the number of transport complexes is sufficiently large so that they can be treated as a continuum "fluid". However, this assumption is oversimplified, so that cannot capture the random fluctuation generated by the discrete nature of the transport system. In this project, we study the intrinsic noise by (i) tracking probability distribution of a single particle and then (ii) using queuing theory to analyze the effect of multiple particles.
 
  • H Kim and P C Bressloff. Intrinsic noise in protein bursting model of flagellar length control In preparation (2019+)
 
Interesting References