I mathematically model the homeostatic regulation of memory CD8+ T
cells via competition for various interleukins
(IL-15, IL-2, and IL-7). These cytokines signal survival,
proliferation, and apoptosis in CD8+ T cells, and competing
effects of these chemicals are likely responsible for the remarkable
constancy of the memory CD8+ T cell compartment
between infections in adults. A mechanistic mathematical model
of memory regulation will be used to analytically
explore shifts in the memory T cell repertoire (i.e., the lineages that
comprise the memory compartment) following
infection and homeostatic
expansion.
Teaching:
Fall 2008: Math
Biology REU
Spring 2008: Journal
Club
Fall 2007: Journal
Club Spring 2007: Math 1180
- Calculus for Biologists II Fall 2006:
Math 1170 - Calculus for Biologists I Spring 2006: Math
1100 -
Business Calculus Fall 2005:
Math 1030 - Quantitative Analysis