Professor Paul C Bressloff

Contact details
Department of Mathematics
University of Utah
155 South 1400 East
Salt Lake City
Utah 84112
Tel.: 801 585 1633
Fax.: 801 581 4148
Email: bressloff@math.utah.edu


News
New! Distinguished Scholarly and Creative Researcher Award, University of Utah (2017).
New! Congratulations to Dr. Bin Xu, who successfully defended her thesis on Mar 3rd 2017. Bin joins the Department of Applied Mathematics (Notre Dame) as a postdoctoral fellow in June 2017.
New! Congratulations to Dr. Bhargav Karamched, who successfully defended his thesis on Feb 27th 2017. Bhargav joins the Department of Mathematics (University of Houston) as a postdoctoral fellow in June 2017.
New! Congratulations to Dr. James Maclaurin, who will be joining our group as a 3year postdoctoral fellow in July 2017. This position is jointly funded by the NSF and the Department of Mathematics.
New! P. C. Bressloff. Topical review: Stochastic switching in biology: from genotype to phenotype J. Phys. A 50 133001 (2017)
Elected a Fellow of the Society for Industrial and Applied Mathematics (2016)
Appointed Associate Editor of the SIAM Journal of Applied Mathematics (2015)
Plenary speaker: SIAM Conference on Nonlinear waves and Coherent Structures (2014)
Published two books for Springer (2014): Stochastic Processes in Cell Biology, Waves in Neural Media
Biophysics and Stochastic Processes
A major goal of this research is to understand the fundamental biophysical mechanisms underlying cellular function in health and disease. This includes both single cells and multicellular systems. Our work draws upon a wide variety of methods in applied mathematics and theoretical physics including stochastic processes, statistical physics, nonlinear PDEs, and dynamical systems theory. Applications range from molecular and cellular neuroscience to gene networks to bacterial cell polarization and quorum sensing. We are also developing new mathematical and numerical methods for analyzing complex and stochastic nonlinear systems. Current research topics include the following:
Biological processes in switching environments: diffusion in domains with randomly switching boundaries; diffusionlimited reactions; stochastic gap junctions; genetic switches; bacterial persistence in switching environments
Intracellular transport: molecular motors; synaptic democracy and axonal transport; exclusion processes; aggregation models of intracellular transport; random intermittent search;
Cell polarization: active transport in budding yeast; MT regulation in growth cones; symmetry unbreaking in fission yeast
Intracellular pattern formation: Turing mechanism and active transport; synaptogenesis in C elegans
Cellular length control: axonal length sensing, intraflagellar transport
Stochastic hybrid systems: stochastic ion channels; large deviations and pathintegrals; switching master equations
Quorum sensing: coupled PDEODE systems; stochastic models and moment closure
Mathematical Neuroscience
Our research in this area focuses on the spatiotemporal dynamics of continuum neural fields. Neural fields model the largescale dynamics of spatially structured biological neural networks in terms of nonlinear integrodifferential equations, whose associated integral kernels represent the spatial distribution of neuronal synaptic connections. They provide an important example of spatially extended excitable systems with nonlocal interactions, and exhibit a wide range of spatially coherent dynamics, including traveling waves, oscillations and Turinglike patterns. Current research topics include the following:
Neural field models of visual cortex: traveling waves; pattern formation and visual hallucinations; symmetric bifurcations; laminar neural fields.
Stochastic neural fields: stochastic hybrid models of neural networks; large deviation theory and bistability; stochastic traveling waves
Neural field models of binocular rivalry waves
Paul C. Bressloff Stochastic Processes in Cell Biology Interdisciplinary Applied Mathematics (Springer) August (2014)
Supplementary material
Paul C. Bressloff Waves in Neural Media: From Single Neurons to Neural Fields Lecture Notes on Mathematical Modeling in the Life Sciences (Springer) Published (2014)
Stephen Coombes and Paul C. Bressloff(eds.) Bursting: the Genesis of Rhythm in the Nervous System World Scientific (2005)
Hyunjoong Kim (Utah)
Stochastic processes in cell biology (2nd year)
Bridget Fan (Utah)
Quorum sensing (3rd year)
Patrick Murphy (Utah)
Stochastic processes in cell biology (3rd year)
Ethan Levien (Utah)
Biological processes in switching environments (4th year)
Sam Carroll (Utah)
Neural field theory (5th year)
Heather Brooks (Utah)
Intracellular pattern formation (5th year)
Bin Xu (Utah)
Mathematical models of cell polarization (Ph. D 2017)
Bhargav Karamched (Utah)
Mathematical models of motorbased intracellular transport (Ph. D 2017)
Matthew Webber (Oxford)
Stochastic neural field models of binocular rivalry waves (D. Phil. 2013)
Yi Ming Lai (Oxford) Stochastic population oscillators in ecology and neuroscience (D. Phil. 2013)
Jay Newby (Utah)
Molecular motorbased models of random intermittent search in dendrites (Ph. D 2010)
Zachary Kilpatrick (Utah)
Spatially structured waves and oscillations in neuronal networks with synaptic depression and adaptation (Ph. D 2010)
William Nesse (Utah)
Random fluctuations in dynamical neural networks. (Ph. D 2008)
Berton Earnshaw (Utah)
Biophysical models of AMPA receptor trafficking and synaptic plasticity (Ph. D 2007)
Andrew M. Oster (Utah)
Models of cortical development (Ph. D 2006)
Stefanos E. Folias (Utah)
Stimulusinduced waves and breathers in excitable neural media (Ph. D 2005)
Matthew James
Oscillations and waves in IF networks (Ph. D 2002)
Barry de Souza Dynamics of neuronal networks with dendritic interactions (Ph. D 2000)
Peter Roper Noiseinduced effects in neural systems (Ph. D 1998)
Postdocs
James Maclaurin (2017)
Sean Lawley (20142016)
Jay Newby (20102012)
Berton Earnshaw (20072009)
Lars Schwabe (20052006)
Steve Coombes (19961998)
Spatially Distributed Stochastic Dynamical Systems in Biology Isaac Newton Institute, Cambridge, UK, June 2024, 2016
The First International Conference on Mathematical NeuroScience (ICMNS), Antibes, JuanLesPins, France, June 810, 2015
Axonal Transport and Neuronal Mechanics, Mathematical Biosciences Institute, Ohio State, November 37, 2014
SIAM Conference on Nonlinear Waves and Coherent Structures, University of Cambridge, August 1114, 2014
Stochastic Network Models of Neocortex (a Festschrift for Jack Cowan), Banff International research station, July 1318, 2014
Nonlinear dynamics and stochastic methods: from neuroscience to other biological applications (Bard Ermentrout’s 60th) University of Pittsburgh, March 1012, 2014
Oxford Conference on Challenges in Applied Mathematics University of Oxford, July 15, 2013
Stochastic Modeling of Biological Processes, IMA, University of Minnesota, May 1317, 2013
Random models in neuroscience Université Pierre et Marie Curie, July 26, 2012
Stochastic Modelling in Biological Systems, University of Oxford, March 1823, 2012
SpatioTemporal Evolution Equations and Neural Fields, CIRM, Marseilles, October 2428, 2011
Utah

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