Mathematical Biology Seminar

Vicente Planelles, Ph.D.
Professor of Pathology
University of Utah School of Medicine
Wednesday Dec.2, 2009
3:05pm in LCB 225
"Recent studies on HIV-1 latency and reactivation"

Abstract: Treatment with antiretroviral therapy can potently suppress HIV-1 replication, but is unable, to this date, to erradicate infection. A long-lived latent reservoir has been found in the memory compartment of CD4+ T cells. The dynamics of this reservoir are modulated by antigen recognition, cellular activation, inflammatory signals, and the homeostasis of memory cells. My laboratory has developed a unique ex vivo system that allows for the establishment and the detailed study and manipulation of latently infected, primary memory cells. Results arising from this system will be discussed in the context of the current thinking in the field.