Mathematical Biology seminar|
Dept of Biology
University of British Columbia
"Virus competition at multiple scales"
November 2, 2005
3:05pm, LCB 215
Viruses compete and are subject to natural selection at multiple levels:
within-cell, within-host and within-population (of hosts). We looked at
how viruses can optimally exploit their hosts and how this behaviour may
influence the most successful strategy at the between-host, or
epidemiological level. I will present a fairly general way to consistently
combine models of disease process and disease spread with the goal of
understanding the net selection pressure on a model virus. The method is
illustrated using a popular model for HIV dynamics nested within a simple
epidemiological model. This is joint work with Mike Gilchrist (Tennessee).