Mathematical Biology Seminar|
University of Utah
Wednesday March 10, 2010
3:05pm in LCB 215
Mechanisms of length regulation of
flagella in Salmonella
The construction of flagellar motors is a carefully regulated genetic
process. Among the structures that are built are the hook and the
filament. The length of the hook is tightly controlled while the
length of filaments is less so. However, if a filament is broken off
it will regrow, while a broken hook will not regrow.
The question that will be addressed in this talk is how Salmonella
detects and regulates the length of these structures. This is related
to the more general question of how physical properties (such as size
or length) can be detected by chemical signals and what those
mechanisms are. This is related, for example, to the question of how
bacterial populations can determine the size of the colony in which
they live (quorum sensing).
In this talk, I will present mathematical models for the regulation
of hook and filament length and for quorum sensing in bacterial
populations, detailing the significant differences between these as
identifying their common features.