Mathematical Biology seminar|
Huntsman Cancer Institute, University of Utah
""Multi-step skin carcinogenesis"
3:05pm in LCB 215
The mechanism by which a single mutant cell clonally expands is
usually assumed to involve an additional mutation in a cell cycle
regulatory gene. An alternative mechanism for driving clonal expansion is
apoptosis, which might create vacant stem cell compartments that can be
re-populated by mutant cells. This model predicts that in a mouse with
reduced apoptosis capacity i) more mutated cells will appear initially but
ii) these cells will expand into clones more slowly than in wild-type
animals. Experiments with transgenic mice with reduced apoptosis show
that apoptosis does appear to suppress two stages that involve new
mutations - initiation and malignant conversion - yet drives clonal
expansion of existing mutant cells.