Mathematical Biology Seminar|
Donald K. Blumenthal, Ph.D.
Pharmacology & Toxicology, University of Utah
Wednesday March 9, 2005
3:05pm in LCB 121
" The Role of Protein Kinase A in Cardiac Function and
Dysfunction: Opportunities for applying computational biology to an
important biomedical system"
The role of cAMP and its target, the cAMP-dependent
protein kinase (also known as Protein Kinase A or PKA), in regulating
myocardial function has been the subject of intense study for many
decades. Recent technological developments in several areas
including cell imaging, heterologous expression of proteins,
transgenic and knockout animals has made it feasible to begin
developing in silico models of this important signaling pathway that
can be used to better understand the role of individaul components in
the pathway, and the consequences of perturbing effects such as
mutations and drugs. This lecture will review the current state of
the art with regard to PKA signaling in cardiac myocytes and the many
opportunities for mathematical biologists to aid in understanding
important disease processes such as cardiac hypertrophy, heart
failure, and cardiac arrhythmias.