Mathematical Biology Seminar Markus Babst University of Utah Wednesday, March 1, 2006 "Regulation of the AAA-type ATPase Vps4" In eukaryotic cells the degradation of transmembrane proteins in the lysosome is mediated by the protein sorting function of the ESCRT complexes. Regulating the ESCRTs is essential to ensure proper cell surface protein composition and therefore plays an important role in numerous cellular functions such as nutrient uptake, cell communication and immune response. The AAA-type ATPase Vps4 controls the membrane association of the ESCRT machinery and therefore is a key factor in the regulation of the lysosomal degradation pathway. Babst, M. A protein's final ESCRT. 2005. Traffic 6: 2-9