Mathematical Biology seminar
Colin Dale
Dept of Biology
"Type-III secretion systems"
October 26, 2005
3:05pm, LCB 215
Sodalis glossinidius, a maternally transmitted endosymbiont of tsetse
flies, maintains two phylogenetically distinct type-III secretion
systems encoded by chromosomal symbiosis regions designated SSR-1 and
SSR-2. Although both symbiosis regions are closely related to extant
pathogenicity islands with similar gene inventories, SSR-2 has undergone novel
degenerative adaptations in the transition to mutualism. Notably,
SSR-2 lacks homologs of genes found in SSR-1 that encode secreted effector
proteins known to facilitate the host cell cytoskeletal rearrangements
necessary for bacterial entry and uptake into eukaryotic cells. Also,
as a result of relaxed selection, SSR-2 has undergone inactivation
of genes encoding components of the type-III secretion system needle
substructure.
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Mathematical Biology Program
Department of Mathematics
University of Utah
155 South 1400 East Room 233
Salt Lake City, UT 84112
rasmusse@math.utah.edu
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